Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection.
نویسندگان
چکیده
Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.
منابع مشابه
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عنوان ژورنال:
- Infection and immunity
دوره 68 7 شماره
صفحات -
تاریخ انتشار 2000